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Elevated IGF-1 levels are associated with increased cancer risk in observational studies, particularly for hormone-sensitive tumors. Pollak, Nature Reviews Cancer Avoid use if you have: Personal or family history of cancer Undiagnosed growths or polyps A genetic predisposition to hormone-related cancers Diabetics and Individuals with Insulin Resistance IGF-1 directly affects glucose uptake and insulin signaling

This tends to be more common if youre also taking insulin or medications like sulfonylureas for type 2 diabetes