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doi: 10.1016/j.ajpath.2014.04.015 101 KorkmazBJailletJJourdanMLGauthierAGauthierFAttucciS

It usually presents with pathological changes of glomerular filtration rate below 15 ml/(min1.73m^2), accompanied by retention of metabolites and toxins, and disturbance of water, electrolyte and acid-base balance as the main clinical features (Wouk, 2021)

rigorous human clinical trials are limited

Due to the instability of vitamin B12, the admixture of other medicinal substances can cause the vitamin to lose its effectiveness

For patients without absorption disorders, high-dose oral B12 supplements (1,000-2,000 mcg daily) have been shown to be comparably effective to injections in correcting mild to moderate deficiency