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Major Congenital Malformations The NAAED Pregnancy Registry indicates an increased risk of major congenital malformations, including but not limited to oral clefts in infants exposed to topiramate during the first trimester of pregnancy

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Studies in fly models of PD treated with NAM, NAD + , or through PARP mutations demonstrated increased NAD + levels, which also rescued mitochondrial function 283,284,285

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In addition, the indications for the appointment of valproate have been expanding in recent years in connection with the study of the mechanism of action of therapeutic and toxic metabolites of VPA in the human body