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Starting at a lower dose significantly reduces the risk of nausea and GI side effects during the adjustment period

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Metformin is also known to inhibit intestinal bile acid absorption [11] and modulate the composition of the gut microbiota [38], although neither is likely to be of relevance to the observations in the present study as glucose is a weak stimulus for gallbladder emptying and the current study was only conducted in an acute setting

Redox Biol 24:101223 Janbaz KH, Saeed SA, Gilani AH (2002) Protective effect of rutin on Paracetamol-and CCl4-induced hepatotoxicity in rodents

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