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Research indicates glutathione depletion correlates with poor sleep quality, delayed recovery from physical stress, and impaired immune function

Basically the authors say that these are basically preventable environmental factors like high iodine intake, selenium deficiency, pollutants such as tobacco smoke and industrial smug, as well as infectious diseases and certain drugs

The cells were subsequently treated with DCFH-DA (10 M, Bio-lab) for 1 h in the dark, and washed three times with PBS