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You suspect something is off hormonally or metabolically Insulin resistance, thyroid dysfunction, cortisol imbalance these conditions make weight loss extremely difficult and are frequently overlooked in conventional care

Consistent with our previous results (Jing et al., 2022), lenvatinib significantly reduced L-carnitine content (Figure 2) and downregulated the expression of carnitine-related (Figure 3A) and OXPHOS proteins (Figure 3B) in the skeletal muscle on day 15 of treatment initiation

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This means the skin darkens through the same biological pathway but without UV-induced cell damage