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Taken together this study shows that the liver endothelial layer, mainly LSECs, represent a direct target of the cytotoxic effect of paracetamol and that activation of TRAIL receptor synergistically enhances paracetamol-induced LSEC death via the mitochondrial apoptotic pathway

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doi: 10.1530/EJE-13-0060 6 Espinosa-de-los-MonterosALSosaEMartinezNMercadoM