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The general thiol reagent, 5-5'-dithiobis[2-nitrobenzoic acid] (DTNB, Ellman's Reagent) reacts with GSH to form the 412 nm chromophore, 5-thionitrobenzoic acid (TNB) and GS-TNB

Preclinical Studies in Ototoxicity Models A study carried out both in cultured cells and in an animal model (male and female mice) demonstrated the strong benecial potential of ALA in rescuing ototoxic hearing loss caused by cisplatin

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Microglia showed roughly 2-fold lower, and neurons showed roughly 4-fold lower SLC25A1 expression than astrocytes (Supplementary Table 1