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We found significant differences between children with ASD and control children regarding studies measuring plasma methionine, serum vitamin B9, serum vitamin D, and plasma GSH levels (eFig

Abbreviations ABS Abnormal behavior checklist ADI Acceptable daily intake ADOS- 2 Autism diagnostic observation schedule AGEs Glycation end products ASD Autism spectrum disorder ATEC Autism treatment evaluation test ATP Adenosine triphosphate BHA Butylated hydroxyanisole BHT Butylated hydroxytoluene CARS- 2 Childhood autism rating scale dACC Dorsal anterior cingulate cortex DHA Docosahexaenoic acid DSM- 5 Diagnostic and Statistical Manual of Mental Disorders fifth edition EPA Eicosapentaenoic acid FODMAP Fermented soluble oligosaccharides disaccharides monosaccharides and polyols GABA Gamma aminobutyric acid GARS- 2 Gilliam autism rating scale GFCF Gluten-free-casein-free GSH Glutathione GSH-Px Glutathione peroxidase HDAC2 Histone deacetylase 2 IQ Intelligence quotient IL- 6 Interleukin-6 IL- 1 Interleukin-1 lgG Immunoglobulin G MCT Medium chain triglyceride MMP- 9 Matrix metalloproteinases NAA N-acetylaspartate PFC Prefrontal cortex PUFA Polyunsaturated fatty acids ROS Reactive oxygen species SRS Social sensitivity scale TBHQ Tert-butylhydroquinone tCr Total creatine tNAA Total N-acetylaspartate TNF- Tumor necrosis factor- UVB Ultraviolet B VDR Vitamin D receptor 18 FDG PET 18 Fluoro-deoxyglucos Author Contributions N.S

doi: 10.20632/vso.28.3_235 253

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