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Moreover, genetic factors might modify the risk of NTDs by increasing the susceptibility to folate deficiency during pregnancy

The authors stress that the trial was terminated to determine the severity of the skin-related AEs and that no participants discontinued the study due to pigmentation effects

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The quality evidence of TST90, weight, waist circumference, weight% change, SBP, DBP, TC, LDL, serious adverse events, and non-serious adverse events was moderate