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Ethics statement The studies involving humans were approved by Ethical Committees of the Instituto de Biologa y Medicina Experimental, Buenos Aires (Ref: CE 001/April 2019)
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Excessive TrkB activation could alter seizure thresholds, though PE-22-28 appears to have seizure-protective properties that somewhat mitigate this concern
doi:10.1136/bmjsem-2018-000414 13 Gle A, Trk Y, Aydin BK, Erkoak F, Safal S, Ugurluoglu C
Some researchers report observing initial changes within one to two weeks, while more significant structural changes would be assessed over a full 4-8 week cycle
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