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Moreover, distinct cytokine signatures have been associated with varying severity levels of ME/CFS, where higher levels of plasma pro-inflammatory cytokines, such as colony-stimulating factor 2 (CSF2), correlate with increased physical and fatigue symptoms in these patients (Giloteaux et al., 2023)

Mechanism: Semaglutide acts on GLP-1 receptors

They are once-weekly injections that share identical dosing schedules and strengths

147 Leptin binds to the leptin receptor (LepRb) and activates JAK2/STAT3 pathway to decrease body weight and normalizes blood glucose concentration, meanwhile, JAK2 stimulates the phosphorylation of insulin receptor substrate (IRS1/2), then activates PI3K/Akt pathway and directly affect insulin action

While this study highlights the promising potential of senotherapy in oncology, several limitations warrant consideration