GLP-1 RAs not only ameliorate insulin resistance and microvascular injury [84], which are significant determinants of depression in T2DM, but also enhance dopamine metabolism and stimulate growth factor signaling pathways, suggesting potential neuroprotective functions [85,86]
This creates a cascade of metabolic dysfunction that makes traditional weight management approaches less effective during perimenopause.[2] GLP-1 Receptor Agonists: Mechanisms of Action in Perimenopause GLP-1 receptor agonists work through multiple pathways that are particularly relevant to perimenopausal women: Appetite Regulation and Satiety These medications reduce appetite and food cravings by activating satiety centers in the brain and slowing gastric emptying
Most patients continue losing 12 pounds per week once diarrhea resolves
Most importantly, it demonstrates significant protective and reparative properties in tissues, including anti-inflammatory effects, enhanced cellular repair, and enhanced collagen synthesis
NICE HbA1c should be measured every 36 months until stable on unchanging therapy, then every 6 months