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If untreated for too long, it can lead to permanent dysfunction of the hand, including loss of sensation in the fingers and weakness

Upon activation of cell death induced by hepatic stimuli, IL-1 family cytokines released by dying liver cells stimulate the recruitment of immune cells, which in turn affect inflammation and subsequent liver damage

The immune system produces antibodies against thyroid proteins, such as TPO and thyroglobulin (Tg), leading to thyroid cell damage and eventual hypothyroidism [75]

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