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When GLP-1R, a G protein-coupled receptor, is activated, adenylate cyclase is activated resulting in ATP convertion to cAMP (Meloni, DeYoung, Lowe & Parkes, 2013)
Its FDA label has grown from a single T2D indication in 2017 to six approved indications by early 2026: type 2 diabetes, chronic weight management (injectable and oral), cardiovascular risk reduction, chronic kidney disease protection, and MASH
Reduces glucagon secretion, which helps lower blood sugar