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Sodium glucose cotransporter-2 inhibition in heart failure: potential mechanisms, clinical applications, and summary of clinical trials

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Clinical Efficacy In landmark clinical trials, GLP-1 therapies demonstrated: 15-20% Average weight loss with Semaglutide Up to 22% Average weight loss with Tirzepatide 94% Of patients maintained weight loss after 2 years (with continued treatment) Which Weight Loss Approach Is Right for You

The first half describes a confirmed finding in animals

In addition, evidence from recent experimental studies suggests that most GLP-1 analogues can be injected peripherally and absorbed into the brain, indicating that they could cross the blood-brain barrier (BBB) and exert physiological influences directly on the human brain (72) (detail seen Box 2 )