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Also, in patients with chronic cholestasis, impaired delivery of bile salts to the duodenum results in malabsorption of lipids and fat-soluble vitamins, leading to deficiencies in vitamins A, D, E, and K (see Chapters 31 and 52)

TXNRDs catalyze the reduction of a wide range of substrates, including thioredoxin and protein disulfide isomerase (PDI) (see Figure 2b )

10.1016/j.jnutbio.2019.01.007 436 TianP.ZouR.SongL.ZhangX.JiangB.WangG.et al

**Low levels of zinc in the body** Glutathione may contribute to reducing zinc levels in the body, which may affect multiple aspects of health, such as immune function, skin health, and even hair health

Without testing, treatment becomes guesswork, which can lead to poor results or unwanted side effects