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GLP-1 is a member of the incretin neuropeptide family, secreted by intestinal enteroendocrine L-cells of the distal ileum and large intestine [4, 5] and also in the nucleus of the solitary tract (NTS) in response to nutrient intake [6, 7]

Semaglutide influences regions of the hypothalamus that govern hunger, turning down both the urge to eat and the mental food noise those persistent cravings and thoughts about your next meal

Semaglutide (Ozempic, Wegovy) Semaglutide constipation rates run around 24-29% in clinical trials

Because it is water-soluble, your body naturally filters out excess through the kidneys and excretes it in urine

Your insulin levels increase immediately after a meal, and this action of semaglutide makes your blood sugar levels drop