10.1002/hep.27368 11 EslamM.SanyalA
The World Health Organization's December 2025 guidelines emphasized the importance of resistance training to protect muscle mass during GLP-1 therapy, acknowledging this as a limitation of current treatment approaches [49]
Patients presenting with deep-seated metabolic resistance, hypothyroidism, menopausal hormonal shifts, or chronic inflammatory states often struggle to lose weight even when adhering to strict caloric deficits
However, for longer trips or hot outdoor conditions in Florida, using an insulated medical cooler case is recommended to protect the medication from heat exposure
Both interventions delay gastric emptying and enhance satiety signalling, raising theoretical concerns about additive gastrointestinal side effects such as nausea, vomiting, and potential nutritional deficiencies