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Dosis en estudios animales: En la gran mayora de los estudios preclnicos, las dosis utilizadas en la rata se sitan entre 10 g/kg y 10 ng/kg de peso corporal, administradas por va intraperitoneal u oral

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Brain 103 , 179210 (1980)

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Nevertheless, the direction of effect was consistent: 15 of 18 individual point estimates lay on the increased-risk side of the null, and the pooled result remained statistically significant under both the DerSimonianLaird and restricted maximum-likelihood estimators