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4 GLP-1RAs (eg, tirzepatide, semaglutide, and liraglutide) are synthetic peptides that mimic endogenous GLP-1, and use of these therapies has expanded beyond their metabolic functions in type 2 diabetes and weight loss into other diseases due to their anti-inflammatory properties and their ability to modulate immune function

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For example, in the SELECT trial (17,600 patients with cardiovascular disease and obesity but without T2D), weekly subcutaneous Semaglutide (2.4 mg) reduced the risk of major adverse cardiovascular events (MACE heart attack, stroke, or cardiovascular death) by 20% compared to placebo (HR 0.80

Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults