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Animals were trained to self-administer intravenous cocaine (0.75 mg/kg/infusion) under a fixed-ratio 1 schedule, followed by extinction and reinstatement testing
GLP-1RAs were initially developed as agents to control blood glucose in individuals with diabetes, but CVOTs over the last decade have established these medications as a cornerstone for the reduction of CV events in high-risk populations
So there's added benefit of using this type of medication in someone who has obesity and has harm to their health
ELIXA trial included patients with recent cardiovascular event (patients with acute coronary syndrome 180 days before randomization), and although there was no benefit in MACE reduction in lixisenatide treated patients compared to placebo, results revealed cardiovascular safety of lixisenatide in this specific high risk population (38, 40)
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