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Hair loss is not listed as a common side effect on official prescribing information, but it has been reported by many people taking GLP-1 injections

In terms of the magnitude of fat mass reduction in controlled research settings: Semaglutide (GLP-1 alone): ~1015% body weight Tirzepatide (GLP-1 + GIP): ~1622% body weight Retatrutide (GLP-1 + GIP + Glucagon): ~2429% body weight (Phase 2 data) This stepwise increase with each additional receptor target is a remarkable demonstration of pharmacological synergy and has driven enormous interest in the triple-agonist research space

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The individualized dosing model with weekly provider-reviewed check-ins represents a higher-touch monitoring model compared to fixed-schedule escalation alternatives