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Of these substrates, cysteine availability is rate-limiting, rendering glutathione synthesis particularly sensitive to dietary protein quality, sulfur amino acid intake, and intracellular redox demand

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Pregnancy itself: the most common cause

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J Biol Chem 282:3264054 Humphries KM, Juliano C, Taylor SS (2002) Regulation of cAMP-dependent protein kinase activity by glutathionylation

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Knepper, P.S.T

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