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regulation of metabolic pathways calcium homeostasis remodeling of cytoskeleton inflammation protein folding Other Vital Roles of glutathione (GSH) include

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

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Nicotine & Tobacco Research, 23(10), 16821690.

Limitations of this technique are the potential impact of the handling (medium and storage) on metabolite levels, the impossibility of combining with phenotypic analyses, the cost of the equipment and the variability resulting of the metabolites quenching and purification that can change rapidly the level of metabolites