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The neurons in the affected network compensate for this weak or absent signals by increasing the number of neuro-transmitter receptors

(March 2014)

GLS inhibitors, such as CB-839, have been shown to impair GSC survival by inducing metabolic stress and triggering the amino acid deprivation response pathway, thereby increasing their susceptibility to chemotherapy

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An example of the resulting plasma concentration/time profile is shown in Figure 33, dihexa exhibited rapidly decreasing plasma levels from 0 to 4 hours suggesting that both distribution and elimination occurred during this period