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Thus, in vitro affinity data alone cannot accurately predict therapeutic performance, highlighting the need for QSP models that integrate receptor kinetics, tissue expression, and signaling bias to better forecast clinical potency and safety

Curr Rev Clin Exp Pharmacol, 17 (3), 205-15

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Co-exposure of cardiomyocytes to IFN- and TNF- Induces mitochondrial dysfunction and nitro-oxidative stress: implications for the pathogenesis of chronic chagas disease cardiomyopathy

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