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Diabetes Care 30:842847 Morris JK, Bomhoff GL, Gorres BK, Davis VA, Kim J et al (2011) Insulin resistance impairs nigrostriatal dopamine function

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7.2.1 Non-monotonic dose-response relationships 7.2.1.1 Mechanistic understanding of NMDR effects Many EEDs exhibit non-monotonic dose-response curves where low-dose exposure produces greater biological effects than high-dose exposure (139)

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This gradual increase helps to minimise side effects and allows the body to adjust to the medication effectively