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The acylcarnitine is then transported across the inner mitochondrial membrane for use in OXPHOS.[ref] Related article: Carnitine and mitochondrial transport The first step for using fatty acids in oxidative phosphorylation is breaking them down within the inner membrane by dehydrogenase enzymes
According to recent reports, SIRT1 contributes to cellular lifespan extension, resistance to oxidative stress, and repair of DNA damage (Elshazly et al