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9 A mandated risk-management program (iPLEDGE) was introduced in 2006 to prevent isotretinoin exposures during pregnancy in patients who can become pregnant and to document the frequency and outcomes of isotretinoin exposure during pregnancy

Prolonged overdose of B6 (150-200 mg/day) over weeks can cause severe sensory-nervous-system dysfunction and ataxia.37 With normal usage serious adverse effects are not reported for pyridoxine (vitamin B6), however, diarrhoea, emesis and rosacea-like dermatitis may be observed in some cases (38)

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GLP-1s target underlying causes like obesity but dont directly treat the airway blockages that cause OSA