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By suppressing miR-10b, GAS5 upregulation enhances BDNF mRNA levels, contributing to curcumins antidepressant effects in PSD via the GAS5/miR-10b/BDNF regulatory axis (Cai et al., 2020)

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4 Central GLP-1R pathways linking metabolic regulation and addiction circuits GLP-1 Rs are broadly distributed in brain circuits that play pivotal roles in motivation, including the striatum, hypothalamus, ventral tegmental area (VTA), and extended limbic regions such as the central amygdala and the infralimbic/prelimbic cortex (Pyke et al., 2014

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