TB-500s biological activity is mediated primarily through binding of the LKKTETQ actin-binding motif to G-actin and sequestering actin monomers, regulating actin polymerisation dynamics, and activating downstream signalling through the PI3K/Akt pathway that promotes cell survival, migration, and proliferation in multiple cell types relevant to tissue repair including endothelial cells, fibroblasts, keratinocytes, and myocytes
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[DOI] [PMC free article] [PubMed] [Google Scholar] Ow R.A., Soler Z.M., Sindwani R., Leopold D.A., Lee J.T., Mahmoud R.A., et al
Why Does GHK-Cu Sting on Injection
