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In about 17,600 adults with obesity and established cardiovascular disease but no diabetes, semaglutide cut major cardiovascular events by 20% over roughly 40 months. This is a secondary-prevention result in people who already had heart disease

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Contraindications, Drug Interactions, and Monitoring Important precautions include: Avoiding use in active, untreated malignancies due to theoretical tumor-promotion concerns Using caution with immunosuppressants Monitoring blood pressure and liver enzymes if treatment exceeds six weeks Consulting a healthcare professional if you have bleeding disorders or take anticoagulants Bodybuilders who use multiple compounds should be especially careful because side effects and interactions may be harder to identify