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however, other forms of ROS also contribute as the nitric oxide (NO) generated by NO synthases, which diffuses into mitochondria and modulates mitochondrial function by competing with O 2 at respiratory complex IV thereby slowing respiration (Collins et al., 2 O 2 in thiol oxidation modulating the function of proteins (Collins et al., 2014)

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AMP-activated protein kinase (AMPK) as a master intracellular energy sensor is implicated in the regulation of both glucose and lipid metabolism (33, 86)

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