Ecotoxicol Environ Saf 115:144151
This could be the reason why the bispecific molecules work so well
CJC-1295 vs Ipamorelin Synergistic GH pulse pairing to aid fat loss and recovery

Neurological: convulsions, increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment, vertigo, headache Endocrine: menstrual irregularities, development of cushingoid state, suppression of fetal intrauterine or childhood growth, lack of secondary response of the adrenal cortex or pituitary gland, particularly in situations of stress such as trauma, surgery or illness, decreased carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements of insulin or oral hypoglycemic agents in diabetic patients Ophtalmic: posterior subcapsular cataracts, increased intraocular pressure, glaucoma, exophthalmos Metabolic: negative nitrogen balance due to protein catabolism Psychiatric: euphoria, mood swings, severe depression to frank psychotic manifestations, personality changes, hyperirritability, insomnia Others: anaphylactoid or hypertensive reactions and hypotension or shock-like reaction Cyanocobalamin and hydroxocobalamin: hypervitaminosis and side effects were not observed with their use Dosage and administration Adults Coated tablets: 1 coated tablet 2 times a day

There may be, it has been suggested, two waves of dopamine-mediated responses: one set of faster responses associated with changes in cAMP and DARPP-32 phosphorylation, and another slower set of non-cAMP mediated processes associated with -arrestin-2/Akt/GSK-3 signaling