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Its primary roles include: Stimulating insulin secretion Inhibiting glucagon release Slowing gastric emptying Reducing appetite via central pathways While most known triggers of GLP-1 release are nutrientsespecially fats and carbohydratesrecent research suggests that immune and microbial signals may also stimulate L-cell activity

Guo et al., in a systematic review and meta-analysis including five RCTs and 1604 participants, showed the efficacy and safety of this combination in the reduction of fasting plasma glucose (FPG) level, and 2 h postprandial (2-HPP) glucose, glycosylated hemoglobin (HbA1c), and systolic blood pressure (SBP) [66]

doi: 10.3389/fnins.2022.970925

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