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Given the colocalization of PAR2 within the enteroendocrine populations, we hypothesized that protease-specific PAR2 signaling in the gut might modulate postprandial incretin secretion

Subjective and objective markers for plateau include diminishing benefits after initial improvements, requiring higher doses for same effects, increased side effects relative to benefits, and biomarkers stopping improvement despite continued use

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Yet the way these new weight-loss drugs work may mean the likelihood of putting lost weight back on is even higher