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However, in a rat intestinal perfusion model [107], whether through intracavitary perfusion or vascular perfusion, FXR agonists were unable to stimulate GLP-1 secretion, contrary to previous findings

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The pharmacokinetic profiles of these formulations indicate that maximum plasma concentrations are typically attained within 1 to 3 days following SC administration, while steady-state plasma levels are generally achieved after 4 to 5 weeks of once-weekly dosing

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