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FDA-approved drugs have to prove both safety and effectiveness in human bodies

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For people with genetic predispositions toward higher appetite drive (such as variants in the GLP1R or MC4R genes), this rebound can feel especially intense because their baseline hunger regulation is naturally more aggressive

Diabetes was the most common indication (43.9%)

Resistance to tretinoin may develop due to pharmacokinetic reasons (decreased bioavailability) and/or changes in proteins involved in the cellular activity of tretinoin