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Antioxid Redox Signal (2013) 19:185560
Nevertheless, the discovery of an extra-hepatic IGF-I production in the following years[18, 45], made it necessary to spand the conception of the GH/IGF-I axis, being well accepted nowadays that pituitary GH is able to induce IGF-I synthesis in both liver (~75%) and other tissues[23, 46, 47], which subsequently, is able to act in an endocrine/paracrine/autocrine manner
Urine and serum samples were taken which showed an increase in the serum level five Oxoproline to Creatinine ratio indicating pyroglutamic metabolic acidosis
3.2 Ultrasound-assisted extraction (UAE) Results concerning BoxBehnken (BB) experimental design for the second step (UAE) of the sequential process are presented in Supplementary Table S3
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