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The Aldh2*2 KI mice have a decreased ALDH2 enzyme activity relevant to human ALDH2*2 carriers The Aldh2*2 KI mouse, which has an Aldh2 gene mutation orthologous to the human ALDH2*2 , was generated by genome editing of 1516G in the exon 12 of the endogenous murine Aldh2 locus, via inserting a G-to-A substitution (E504K) by CRISPR-Cas9 system (Fig

Your dose may need to go up during the first 412 weeks as your body adjusts