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They absolutely will test: Rate-limiting step NADH/FADH production Where inhibitors act High-yield enzymes: Citrate synthase Isocitrate dehydrogenase (rate-limiting) -ketoglutarate dehydrogenase (similar cofactors to PDH) Succinate dehydrogenase (complex II of ETC) Key traps: Rate-limiting enzyme of TCA: isocitrate dehydrogenase

Cohorts underwent propensity-score matching at a 1:1 ratio for confounders

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