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The variable absorption rates observed with sublingual administration pose a challenge, requiring careful dose adjustments and individual patient monitoring to optimize treatment

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Butler et al.) This paper was published ten years ago and revolves around the fact that patients with Pernicious Anaemia should be able to passively absorb some B12 through their stomach around 1%

Additionally, the dietary fiber component inulin is effectively converted into vitamin B5 by the fecal microbiota (120), and dietary fiber abundance improves the response to immunotherapy in patients with melanoma (121)