If you are using Wegovy (semaglutide), you are not alone in this experience
One phase IIb clinical trial administered setmelanotide to obese participants with heterozygous MC4R deficiency and obese controls over 28 days, observing a placebo-adjusted weight loss of 2.6 kg and 4.0 kg respectively [98]
Left atrial volume and E/e ratio are crucial parameters in HFpEF and their improvement with GLP1-RA, together with the reduction of inflammation markers, may explain the expected benefits of this class of drugs in patients affected by HFpEF
J Neurochem 159:867886 Ma X-l, Ding Y, Wu L-M, Wang Y-X, Yao Y, Wang Y-X, Zhang Y-G, Niu J-Q, He X-X, Wang Y-Q (2021) The glucagon-like peptide-1 (GLP-1) analog exenatide ameliorates intrauterine adhesions in mice
[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Antonietti M, Frster S