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Similar to neurodegenerative disorders and cognitive impairment, metabolic disease and DM are increasing in prevalence globally with the number of individuals with DM at 420 million and expected to reach 700 million individuals in the year 2045

Interestingly, HS683 cells, which naturally express low levels of SYNCRIP, were more sensitive to erastin-induced ferroptosis (Figure S3A-C)

Genetic Factors: Some people may have a genetic predisposition that affects their ability to produce or utilize glutathione

10.1016/j.arr.2022.101579 18 HosokiR.MatsukiN.KimuraH

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