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These discrepancies can be attributed to the genetic variation among different ethnic backgrounds in fatty acid metabolism plus the complexity of PUFA metabolism (133)

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Additionally, IL-6 can be secreted by FLSs and B cells in the RA synovium and has been closely linked to the pathogenesis of the disease [236]

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By systematically assessing patients' responses, clinicians can determine the effectiveness of various treatment strategies, providing valuable insights for future decision-making