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Following the KEAP1 inactivation, the expression and the nuclear translocation of nuclear factor-erythroid 2 p45-related factor 2 (NRF2) are increased, which subsequently promotes the transcription of antioxidant proteins like superoxide dismutase 2 (SOD2) and heme oxygenase 1 (HO-1), and leads to the mitigation of synovial inflammation

Freezing a mixed multi-use vial can create solution changes and freeze-thaw stress that are not worth accepting unless a protocol specifically requires aliquoted frozen storage

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Finasteride treatment in mice showed decreased cell proliferation in the hippocampus, suggesting that inhibitors of 5-R block neurogenesis