The first filter is simple: can this provider legally treat someone in your state
STEP-1 Trial (Semaglutide 2.4 mg, N=1,961) The STEP-1 trial published in the New England Journal of Medicine reported that among participants receiving semaglutide 2.4 mg subcutaneously once weekly, nausea occurred in 44.2%, diarrhea in 29.7%, vomiting in 24.5%, and constipation in 24.1%, compared to 16.0%, 15.9%, 6.8%, and 11.1% with placebo, respectively [3]
Thats a very different starting point than introducing a foreign chemical mechanism, and it makes a big difference when to start talking about dosing
up to 24% in obesity trials) Constipation (6-17% of patients, dose-dependent) Abdominal pain and dyspepsia (6-11% of patients) These gastrointestinal effects are typically most pronounced during dose escalation and often diminish over time as patients develop tolerance
doi:10.1016/S2213-8587(24)00316-4 Share this: Share on X (Opens in new window) X Discover more from Sarah Hormachea Subscribe to get the latest posts sent to your email.