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Aberrant inflammation is among these [16], associated with other factors, including oxidative stress induced by Reactive Oxygen Species (ROS), glial and astrocyte injury, compromised monoamine secretion, dysregulation of glutamatergic pathways, neuro excitotoxicity, damage to cerebral blood vessels [15, 17], dysfunction in glymphatic processes [18], and disruption of hippocampal function and dorsolateral prefrontal cortex (DLPFC) [19]