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If you want the appetite and cravings side of this story, how stress drives sugar cravings and reward eating, we cover that separately in Cortisol, Cravings, and GLP-1

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449 Notably, a dosage of 10 mg/kg/day of methazolamide significantly improved these parameters, exhibiting similar efficacy to 30 mg/kg/day of acetazolamide

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Finally, genetic modification of cells to increase PC1/3 expression has been shown to improve glucose regulation in animal models (21, 22)

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